The effect of dental caries and restorative biomaterials on IL-1 β and TNF-α levels in the gingival crevicular fluid

Background/Aim. In the spirit of personalized medicine, determining caries biomarkers in saliva and gingival crevicular fluid (GCF) attracts great attention current dental re-search. The concentration GCF cytokines is illustrative depicting processes tooth structures. Their relevance must be inspected with aspects position lesion level. Different impacts restoration materials on IL-1? TNF-? could used as a parameter for estimating local inflammation. This paper aimed to estimate concentrations proinflammatory (IL-1? TNF-?) correlate them extension, position, different restorative biomaterials. Methods. samples were collected from 90 periodontally healthy patients demonstrating at least one proximal intact tooth, baseline, 7 30-days post-treatment. biomarkers? profile was investigated relation levels extension (superficial, pulpitis, gangrenous, root affection), defect size, biomaterial. Results. Before therapy, level significantly associated concentration, lowest gangrenous (C4) superficial (C2). Thirty days after affection (C5) characterized by highest concentration. fillings showed various cytokine changes. CPC induced significant increase more than 70% treated patients. Caries size insignificantly these cytokines, where larger defects followed an average increase. Considering be-fore had caries-affected canines second molars, while GCF. Dental TNF-?), 1st 2nd molars (IL-1?). Conclusion. Inflammation intensity structures directly reflected concentrations. affects levels, depending filling-type material. varied anatomical positions, demonstrated An absence any symptomatic manifestation inflammatory response can considered possible reparation parameter.